Low-temperature cocrystallization

Cocrystallization in Nutraceuticals

Electrochemical Cocrystallization Experiments with Gd2Cl3

Among compounds of metals in anomalously low oxidation states those of the rare earth ele­ ments containing discrete or condensed clusters are of particular interest [1]. The first discovered compound, Gd2Cl3 [2-4], with an oxidation state below + 2 can be prepared in a slow thermal reac­ tion from Gd and GdCl3 at 870-930 K. The reac­ tion can be enhanced by starting from “activated” Gd obtaine...

2D Cocrystallization from H-Bonded Organic Ferroelectrics.

The synthesis of 2D H-bonded cocrystals from the room-temperature ferroelectric organics croconic acid (CA) and 3-hydroxyphenalenone (3-HPLN) is demonstrated through self-assembly on a substrate under ultrahigh vacuum. 2D cocrystal polymorphs of varied stoichiometry were identified with scanning tunneling microscopy, and one of the observed structural building blocks consists of two CA and two ...

In silico screening of dicarboxylic acids for cocrystallization with phenylpiperazine derivatives based on both cocrystallization propensity and solubility advantage

In silico screening was performed to search for binary solids in which a phenylpiperazine-derivative drug was cocrystallized with a dicarboxylic acid. The phenylpiperazine derivative could be any of 61 such drugs, while the dicarboxylic acid could be any of nine such acids. The uniqueness of this approach was that two criteria had to be fulfilled simultaneously, namely a high propensity for coc...

Ordering of dipeptide chains on Cu surfaces through 2D cocrystallization.

We report on the induced ordering of dispersed chiral diphenylalanine (Phe-Phe) chains grown on the anisotropic Cu(110) and isotropic Cu(100) surfaces. Scanning tunneling microscopy (STM) data reveal that 2D extended hybrid molecular motifs can be fabricated by utilizing terephthalic acid (TPA) molecules as linkers. These act as a molecular "glue" to bridge the isolated Phe-Phe chains without a...